The best compliance of the respiratory system, obtained after testing different PEEPs, was similar between the subjects with COVID-19 ARDS and the subjects with non-COVID-19 ARDS (mean ± SD 38 ± 11 mL/cm H2O vs 37 ± 11 mL/cm H2O, respectively P =.

Increased corrected VËE was independently associated with COVID-19 ARDS ( odds ratio 1.24, 95% CI 1.07-1.47 P =. RESULTS: Corrected minute ventilation (VËE), a dead-space ventilation surrogate, was higher in the subjects with COVID-19 ARDS versus in those with non-COVID-19 ARDS (median 12.6 L/min vs 9.4 L/min P <. The association between the ARDS types and dead-space ventilation, compliance of the respiratory system, subjects' characteristics, organ failures, and mechanical ventilation was evaluated by using data collected in the first 24 h of mechanical ventilation. METHODS: A total of 187 subjects with COVID-19 ARDS and 178 subjects with non-COVID-19 ARDS who were undergoing invasive mechanical ventilation were included in the study. We aimed to establish if dead-space ventilation is different in patients with COVID-19 ARDS when compared with patients with non-COVID-19 ARDS.

Natalini G Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy.ĪBSTRACT BACKGROUND: ARDS in patients with coronavirus disease 2019 (COVID-19) is characterized by microcirculatory alterations in the pulmonary vascular bed, which could increase dead-space ventilation more than in non-COVID-19 ARDS.

Lombardi F Department of Anesthesiology and Intensive Care Medicine, Catholic University of The Sacred Heart, Rome, Italy.

Hoxha L Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy.

Mari LM Department of Anesthesiology and Intensive Care Medicine, Catholic University of The Sacred Heart, Rome, Italy.

Tansini F Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy.

Crisci S Department of Anesthesiology and Intensive Care Medicine, Catholic University of The Sacred Heart, Rome, Italy.

Nencini N Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy.Cavallo E Department of Anesthesiology and Intensive Care Medicine, Catholic University of The Sacred Heart, Rome, Italy.Prezioso C Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy. Fusina F Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy.Bertelli M Department of Anesthesia and Intensive Care, Fondazione Poliambulanza Hospital, Brescia, Italy.

Increased dead space ventilation